5.3 HISTOLOGICAL STUDIES

Three years after implantation, Biofibre® are surrounded by hyperplastic epidermis (pseudoinfundibulum) both at the level of the papillary layer of the dermis and in the uppermost part of the reticular dermis.

Within the pseudo-infundibula a compact keratin layer adheres closely to the fibres.
In the middle and deep reticular dermis, the fibres are surrounded by a small amount of focally granulomatous chronic infiltrate.
In the deepest dermis and hypodermis, the fibres are surrounded by fibroplasia and no inflammatory infiltrate is noted.

Ref.: FantI P.A., Pistorale T., D'Urso C., MiscialI C.,
Tosti A., Histological study on 5 cases of patients who
underwent artificial hair implantation without
complications, XXXII Annual Meeting, American Society of
Dermatopathology, New Orleans, February 01-03, 1995.